In more than 70% of cases, it is diagnosed at an advanced phase. Ovarian cancer is the 5th worldwide leading cause of death of women due to cancer. To date, the most efficient biological diagnostic tool to diagnose ovarian cancer is the combination of CA125 and HE4. The specificity of ROMA is lower than HE4 (84% compared to 94%). While the specificity of RMI sometimes reaches 92%, the rather low AUC of 0.86 does not make it the best diagnostic tool. Furthermore, this combined measure of CA125 can correct the variations in HE4 which are due to smoking or contraception combining estrogen plus progestin. The combined measures of CA125 and HE4 have proved to be highly efficient with an area under the curve (AUC) of up to 0.96. Its specificity is 94% and its level is not affected by endometriosis cysts. The level of HE4 is overexpressed in ovarian tumors. Serum CA125 assay has low sensitivity in the early stages and can be increased in certain conditions such as menstruation or endometriosis. Our study aims to give an update on the biological markers for diagnosing ovarian cancer, specifically HE4, CA 125, RMI and ROMA algorithms. In more than 70% of cases, it is only diagnosed at an advanced stage.

Ovarian cancer is the 5th leading cause of death for women with cancer worldwide.

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